Analgesic tablets, also known as Somitol tablets, are a kind of compound preparation. They are widely used as antipyretic and analgesic drugs due to their low price and non-prescription drugs, and are mainly used in clinical practice for fever and mild and moderate pain. Each tablet contains 0.15g aminopyrine, 0.15g phenacetin, 0.05g caffeine and 0.015g phenobarbital.
Containing amidopyrine and/or phenacetin medicines for there are serious security problems are banned or restricted in many countries, the health sector in China in September 1982 formally announced the 127 kinds of eliminating drug, including amidopyrine tablet/injection, phenacetin tablets, but contain amidopyrine and/or phenacetin amidopyrine and phenacetin compound tablet is still used in many places in China. Today the author will talk with you about this commonly used antipyretic analgesic pain tablets.
What is the antipyretic analgesic mechanism that goes painful piece?
Aminopyrine and phenacetin can inhibit the synthesis and release of prostagnationin the hypothalamus, restore the normal reactivity of sensory neurons in the thermoregulatory center and play a role of antipyretic. It can also act as a pain reliever by inhibiting prostaglandin synthesis. Aminopyrine can inhibit prostaglandin synthesis and release in local inflammatory tissues, stabilize lysosomal membrane, affect phagocytosis of phagocytic cells and resist inflammation. Coffee stimulates the cerebral cortex, constricts cerebral blood vessels, and enhances the effects of aminopyrine and phenacetin on headache relief. Phenobarbital has sedative, hypnotic and anticonvulsant effects. It can increase the analgesic effects of aminopyrine and phenacetin and prevent febrile convulsions.
What adverse reaction does go painful piece have?
Aminopyrine can cause severe leukopenia, especially granulocytopenia. Long-term use of compound preparations containing finacillin may cause damage to the kidneys, and in serious cases may lead to renal papillary necrosis, uremia, etc. Methemoglobinemia, atopic dermatitis, granulocytopenia, thrombocytopenia and hepatitis can occur after use of this product. Excessive doses can cause liver damage, coma and even death in severe cases, renal colic and acute renal failure.
There have been reports of poisoning caused by long-term use of this product. There was once a rheumatoid arthritis patient, did not go to the hospital regularly to see rheumatism specialist, the drug store to buy pain tablets to eat more than 10 years, and later went to the hospital to check found kidney failure. The patient takes pain-killer to deal with when each kind of rheumatism attack, take pain-killer to have become a habit, flit past more than 10 years, discover recently period of time the body is not quite right, urination appears difficult, companion has the symptom such as hematuria, diagnose is to take pain-killer for a long time to already caused kidney injury after examining to the hospital.
In a word, the safety risk of pain-relieving tablets cannot be ignored. Its adverse reactions are not only numerous, but also serious, such as granulocytopenia, kidney damage, liver function damage, etc., and can even lead to coma and death. Can replace pain tablets antipyretic analgesic a lot, we still try not to choose pain tablets.