After a novel Coronavirus variant strain was reported in the UK, Guangdong CDC strengthened the sequencing analysis of novel Coronavirus gene sequencing of a case imported from abroad, and conducted a retrospective genetic sequencing analysis of samples of confirmed cases and asymptomatic infected persons imported from abroad since September last year. On 2 January 2021, the Guangdong Provincial Center for Disease Control and Prevention found a mutant strain B.1.1.7 in the throat swab sample of a confirmed COVID-19 imported case from the UK, which is highly similar to the genetic sequence of the mutated virus reported in the UK recently.
The case is a closed-loop British entry, male, 18 years old, Chinese, international student. On 4 December 2020, the novel Coronavirus nucleic acid was tested negative on arrival in Guangzhou from The UK. On December 18, samples were taken at the isolation site and tested positive with novel Coronavirus nucleic acid and sent to guangzhou No. 8 People’s Hospital for isolation treatment. The patient was diagnosed as a confirmed case and the clinical classification was mild.
On December 27, 2020, The Guangdong Provincial Center for Disease Control and Prevention carried out genome sequencing analysis on the throat swab samples collected from the eighth People’s Hospital of Guangzhou, and the preliminary results showed that the strain was B.1.1.7 mutant. High-throughput sequencing was re-performed on January 2, and the results showed that the virus gene sequence in the case sample belonged to subtype B.1.1.7. The viral genome sequence contains 13 branching amino acid mutation sites specific to the subtype B.1.1.7 mutant strain, including S protein N501Y, which has a potentially significant impact on the ability of the virus to infect, and S protein 69-70 deletion mutations associated with the P681H mutation and viral immune escape.
According to the current situation, this b. 1.1.7 mutant has a stronger transmissibility, but the symptoms, severity rate and fatality rate of patients remain basically unchanged.
Recent Comments